Host-Microbiome Relationships in C. elegans guided by natural diversity and environmental factors
Abstract
Microbes are widely diverse and prevalent in nature. Microbial diversity within hosts plays an important hurdle in unraveling the role of each component of the microbiome and its relationships in the host physiology. Caenorhabditis elegans is an important micro-organism that has been well-studied as a model for host-microbiome relationships. The gut of C. elegans has a variety of microbial species which makes it a useful host organism to study the microbiome and the gut-brain axis. Understanding the gut microbiome and its role in modulating the host health has implications to researchers across several fields of study and possibly holds the answers to several human diseases. In recent years, research in synthetic biology, microbiology, genome sequencing, and bioengineering techniques have revolutionized microbiome research. Engineering techniques in microfluidics, 3D printing, organ-on-chip, stem cell biology, and laboratory automation have made it easier to design and fabricate high-throughput experimental platforms with validation from simulation software tools like COMSOL. These technologies hold promise to unravel the composition and functions of various microbiome communities on the functioning of various organs and tissues.
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